The new affiliation comes as current MyNet affiliate WZMY is becoming an independent, while changing call letters to WBIN.
MyNet will add "Law & Order: SVU" and "Cold Case" to its lineup this fall, which airs on weeknights only.
Currently, independent WSBK airs "The Insider" and "Entertainment Tonight" in the 8 p.m. hour weeknights and a half-hour of news starting at 9, followed by off-net comedies.
A CBS-owned station in Miami is also a MyNet affiliate as part of a duopoly.
"The major franchise programming that MyNetworkTV offers is clearly resonating with viewers and advertisers," said Paul Franklin, executive vice president at MyNetworkTV. The net went through various incarnations before settling on its current syndication-type model.