Giving the morning keynote at the Mobile World Congress in Barcelona, DeWolfe told attendees that mobile is at the heart of MySpace's plans to be a ubiquitous social portal.
With only a quarter of its users accessing the site via mobile devices, he said the medium holds enormous potential for the company.
Already, MySpace has signed 59 carrier deals in 20 countries, most recently announcing plans to develop integrated applications for Nokia and Palm devices.
The company has previously created apps tailored to iPhone, BlackBerry, Android and Sidekick devices. Through the spread of smartphones and its international growth, MySpace expects half its traffic to come via mobile phones in the next few years.