Ponturo, 56, is vice president of global media and sports marketing and controls the biggest advertising budget in sports--a powerful enough position that BusinessWeek magazine this year ranked him No. 14 on its list of the 100 most powerful sports executives.
A replacement will not be named until after Anheuser-Busch's $52 billion takeover by Belgian rival InBev NV closes.
Ponturo is retiring on Dec. 31 after 26 years of service, Anheuser-Busch Chief Executive August Busch IV said in a Monday note to employees.--Nina Lentini