The sometime controversial host will host a call-in program that combines her humor with current interests in both the pop culture and news arena.
O'Donnell said she was approached by the company after she appeared on Howard Stern's Sirius XM show earlier this year. She will broadcast from a specially built studio in her New York home.
Scott Greenstein, president and chief content officer, Sirius XM Radio, said that Rosie fans will now have "the chance to call in and talk to her and her intriguing guests," adding that the new show will "entertain, inform, surprise and delight." Sirius did not disclose potential guest lineups.
O'Donnell, who left "The View" in 2007, is known for being outspoken and confrontational, although Sirius says the show will have an ensemble feel. Various guests, including celebrities and everyday people, will join the daily discussion.
"Rosie Radio" will air Monday through Friday from 10 a.m. to 12 p.m. EST on Sirius channel 102 and XM channel 155. O'Donnell joins Sirius XM's roster of well-known women, which includes Oprah Radio, Martha Stewart Living Radio and Barbara Walters.