Hardee's went all out to celebrate its 50th anniversary. It targeted some of its key customers both new (young dudes in their 20s who live on fast food) and old (the Boomers and seniors who grew up eating it). There's one place where these groups meet (besides Hardees, of course): Facebook, where fans were encouraged to share pictures, videos and memories. To celebrate its birthday, the chain also offered a $50,000 giveaway on Facebook and $50 gift cards on Twitter.

Now that ED drugs are advertised on the Super Bowl, men don't have to be shy about sexual issues. And for the 20 million men between 50-64 who may be affected by low testosterone, which impacts their sex drive, there is help. The campaign relied on gentle humor - and a practical, non-threatening approach - to encourage men to seek medical attention. A user-friendly Web site kept the tone light, while encouraging men to visit lowtfacts.com for additional information and a branded treatment solution.

Flu shots have been given for 71 years. Now you have a choice: vaccine or spray in the nose. For kids, it's a no-brainer: They pick their nose. Parents needed to be educated in order to request FluMist from doctors. A clever, fun multimedia effort - I Pick My Nose - hit parents' and iVillage sites, while the campaign dominated YouTube for a day. Banners proclaimed: "Flu has cooties." The effort was on the nose, winning 254 million online impressions and 900,000 video views.

Hospitals, like soft drinks, sell their brands to specific demographics. Both depend on repeat business. NorthShore-Long Island Jewish, an established hospital with 10,000+ doctors, is no different. It aimed to expand on TV spots using CPC online ads to highlight cancer care, women's health, and pediatrics, among its many services. The tone is upbeat, the information straightforward. It's friendly, no-frills approach delivered 178 million impressions and a 28 percent lift in brand favorability. The tagline: "Hope lives here." Let's hope people do, too.

SpaFinder's Wellness Week campaign generated over 75 million impressions in an eight-week period and gained over 100,000 new consumer sign-ups. SpaFinder's mission is to connect consumers with spas the world over. With an already large consumer base, SpaFinder utilized its Wellness Week campaign to offer consumers $50 or 50 percent off spa services nationwide. The tremendous participation made for a successful campaign and very happy sponsors.

Nature Made enlisted Mindshare Los Angeles to spearhead their "Nature Made 2011 WebMD Digital Partnership" campaign. The goal was to establish Nature Made as a trusted vitamins, minerals and supplements maker. Mindshare Los Angeles developed a multipoint campaign to rebrand the company. Nature Made began sponsoring WebMD's Vitamins & Supplements Lifestyle Guide and their Health Assessment Tool, gaining access to all of the site's users. The results were astounding and resulted in a 32 percent brand favorability life.

Greater Than One's "How I Fight MS" campaign follows five adults living with MS through blogs and journals, effectively putting a face to the disease. Along with the personal journeys being followed on the site, there is also an informational section featuring quizzes, FAQs and diagnostic information about MS. The site's design is casual and uplifting, conveying an importance and ease for the campaign.

Style icon and former fatty Karl Lagerfeld and starlet Rachel Bilson teamed up for Magnum Ice Cream's "Pleasure Personified" campaign, which has led to stores barely being able to keep the product on the shelf.

Hellmann's teamed up with celebrity chef Bobby Flay to promote Hellmann's mayonnaise in their "Build the Perfect Sandwich" campaign.

Until recently, Kashi and Cheerios led the market for heart-healthy food.